Recent publications

Trends in first-time treatment admissions for older adults with Alcohol Use Disorder: Availability of medical and specialty clinical services in hospital, residential, and outpatient facilities

Summary: This study describes trends in first-time treatment admissions for older adults with alcohol use disorder in relation to availability of medical and specialty clinical services in hospital, residential, and outpatient facilities.Learn More: Article abstract

Differences is availability and use of medications for opioid use disorder in residential treatment settings in the United States

Summary: This study correlates the differences and availability of the use of medications for opioid use disorder in relation to residential treatment settings in the United States.

Protracted Renal Clearance of Fentanyl in Persons with Opioid Use Disorder

Summary: This study correlates protracted renal clearance of fentanyl in relation to a person with opioid use disorder.

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Integration of Patient-reported Outcomes Assessment into Routine Care for Patients Receiving Residential Treatment for Alcohol and/or Substance Use Disorder

Summary: This study describes the integration of patient-reported outcomes assessment in relation to routine care for patients receiving residential treatment for alcohol and/or substance use disorder.

Evidence of buprenorphine-precipitated withdrawal in persons who use fentanyl

Summary: This study correlates buprenorphine-precipitated withdrawal in relation to a person who uses fentanyl.

Comprehensive pain management as a frontline treatment to address the opioid crisis

Summary: This study correlates comprehensive pain management in relation to a frontline treatment to address the opioid crisis.

Worsening sleep quality across the lifespan and persistent sleep disturbances in persons with opioid use disorder

Summary: This study correlates worsening sleep quality across the lifespan and persistent sleep disturbances in relation to a person with opioid disorder.

Clinical correlates of drug-related dreams in opioid use disorder

Summary: This study correlates drug-related dreams in opioid use disorder.

Latent trajectories of anxiety and depressive symptoms among adults in early treatment for nonmedical use

Summary: This study correlates latent trajectories of anxiety and depressive symptoms in relation to adults in early treatment for nonmedical use.

A double-blind, randomized, placebo-controlled, pilot clinical trial examining buspirone as an adjunctive medication during buprenorphine-assisted supervised opioid withdrawal

Summary: This study is a double-blind, randomized, placebo-controlled, pilot clinical trial examining buspirone as an adjunctive medication in relation to opioid withdrawal.

Patient perceptions of higher dose naloxone nasal spray for opioid overdose

Summary: This study correlates patient perceptions and higher dose naloxone nasal spray in relation to opioid overdose.

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The association of chronic pain and opioid withdrawal in men and women with opioid use disorder

Summary: This study correlates chronic pain and opioid withdrawal in men and women in relation to opioid use disorder.

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Correlates and Consequences of Anxiety and Depressive Symptom Trajectories During Early Treatment for Alcohol Use

Summary: This study correlates anxiety and depression in relation to early alcohol treatment.

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Protracted renal clearance of fentanyl in persons with opioid use disorder

Summary: This study aimed to measure renal clearance of fentanyl in patients with opioid use disorder in our residential treatment program.

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Differences in availability and use of medications for opioid use disorder in residential treatment settings in the United States

Summary: This study analyzed the variance in the administration of medication for opioid use disorder among residential treatment facilities across the United States.

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Trends in first-time treatment admissions for older adults with alcohol use disorder: Availability of medical and specialty clinical services in hospital, residential, and outpatient facilities

Summary: Older adults seeking treatment for alcohol use disorder may need specialized care, including medication supported recovery. In some facilities, this type of treatment is not available.

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Association of sleep disturbance, chronic pain, opioid withdrawal

Summary: There is very little research on sleep disturbances and chronic pain in persons going through opioid withdrawal. This study will examine whether chronic pain worsens opioid withdrawal and sleep disturbances in persons with opioid use disorder.

Status: IRB Approved/Active

A grant-funded multi-site clinical trial to study the relationship among sleep, stress, emotion, drug craving and relapse in outpatient facilities

Summary: There is no published clinical research on the role of the orexin neurotransmitter system in opioid use disorder. This randomized-controlled trial will examine whether a dual-orexin receptor antagonist improves sleep, stress and relapse outcomes in persons in early recovery from opioid use disorder.

Status: IRB Approved/Active

Upcoming studies

Improving treatment quality metrics within Ashley

Summary: We are tracking patient outcomes across a number of indicators to assess the quality of treatment as well as our data collection strategy with Trac9. The program tracked in-program stress, mental health and craving data, as well as numerous quality of life indicators for up to one year following completion of our treatment programs. This data will not only improve our operations and treatment methodologies but will also be viable for academic research purposes.

Proposed topics for future study

• Quantifying outcomes from Ashley’s Pain Recovery Program
• Treatment strategies for older adults with alcohol use disorder
• Medication strategies for opioid withdrawal
• The relationship between spirituality and physiological outcomes (e.g., stress)