Publications
Recent Publications
Protracted renal clearance of fentanyl in persons with opioid use disorder
Summary: This study aimed to measure renal clearance of fentanyl in patients with opioid use disorder in our residential treatment program.
Differences in availability and use of medications for opioid use disorder in residential treatment settings in the United States
Summary: This study analyzed the variance in the administration of medication for opioid use disorder among residential treatment facilities across the United States.
Trends in first-time treatment admissions for older adults with alcohol use disorder: Availability of medical and specialty clinical services in hospital, residential, and outpatient facilities
Summary: Older adults seeking treatment for alcohol use disorder may need specialized care, including medication supported recovery. In some facilities, this type of treatment is not available.
Recent Studies
Physical and mental health improvements during residential treatment for substance use disorders
The goal of this study is to quantify improvements in depression, anxiety, sleep, craving, and quality of life during residential treatment. We also examined whether these improvements persist into early abstinence following residential treatment.
Status: Completed
Clinical trial: Buspirone for the treatment of opioid withdrawal
This randomized-controlled trial examined whether buspirone reduces opioid withdrawal. The study found initial efficacy of buspirone that should be examined in a larger trial.
Status: Completed
Fentanyl elimination in persons with opioid use disorder
This study quantified the time it takes fentanyl to leave the body in individuals who use fentanyl regularly. The average elimination time of fentanyl is 1-2 weeks in this population and can take as long as one month.
Status: Completed
Association of sleep disturbance, chronic pain, opioid withdrawal
There is very little research on sleep disturbances and chronic pain in persons going through opioid withdrawal. This study will examine whether chronic pain worsens opioid withdrawal and sleep disturbances in persons with opioid use disorder.
Status: IRB Approved/Active
Association of sleep disturbance, chronic pain, opioid withdrawal
There is very little research on sleep disturbances and chronic pain in persons going through opioid withdrawal. This study will examine whether chronic pain worsens opioid withdrawal and sleep disturbances in persons with opioid use disorder.
Status: IRB Approved/Active
Grant-funded multi-site clinical trial to study the relationship among sleep, stress, emotion, drug craving, and relapse in outpatient facilities
There is no published clinical research on the role of the orexin neurotransmitter system in opioid use disorder. This randomized-controlled trial will examine whether a dual-orexin receptor antagonist improves sleep, stress, and relapse outcomes in persons in early recovery from opioid use disorder.
Status: IRB Approved/Active
Improving treatment quality metrics within Ashley
We are tracking patient outcomes across a number of indicators to assess the quality of treatment as well as our data collection strategy. The program tracked in-program stress, mental health, and craving data as well as numerous quality of life indicators for up to one year following completion of our treatment programs. This data will not only improve our operations and treatment methodologies but will also be viable for academic research purposes.
Status: IRB Approved/Active
Proposed Topics for Future Study
- Quantifying outcomes from Ashley’s Pain Recovery program
- Treatment strategies for older adults with alcohol use disorder
- Medication strategies for opioid withdrawal
- The relationship between spirituality and physiological outcomes (e.g. stress)
To learn more about Ashley’s research programs, recent publications, and outcomes studies please contact us through the form below.
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